Highly Diastereoselective Synthesis of Atropisomeric Bridged P,N-Ligands and Their Applications in Asymmetric Suzuki–Miyaura Coupling Reaction

Three novel atropisomeric bridged P,N-ligands were prepared using a highly efficient central-to-axial transfer strategy as the protocol. The new chiral ligands were successfully applied in the palladium-catalyzed asymmetric Suzuki–Miyaura coupling reaction, Up to 98% yield and 82% ee were obtained in the enantioselective synthesis of axially chiral biarylphosphonates.