Ocular higher-order aberration features 10 years after photorefractive keratectomy

The aim of the present study is to re-evaluate the original cohort of patients who participated in the first photorefractive keratectomy (PRK) trial in the 1990s, especially their optical performance. Forty-four eyes (24 patients) of the original cohort who underwent PRK using the NIDK EC-5000 excimer laser platform returned 10 years (range 9–14 years) postoperatively to have higher-order aberrations (HOAs) recorded. Wavefront aberrations were measured using Wavescan (VISX, Santa Clara, CA, USA) and calculated for 3- and 6-mm pupil size. The total RMS (the square root of the sum of squared Zernike coefficients) of higher-order wavefront error (3rd–6th radial order) and the Zernike coefficients, as well as the third-order (S 3) and fourth-order (S 4) aberrations, spherical aberrations and coma aberration values were analyzed. An independent sample t test was used for comparisons and a P value <0.05 was considered statistically significant. The mean RMS of higher-order wavefront values showed an increase but no significant difference in postoperative eyes compared to the control-matched normal level with the 6-mm pupil (HOA RMS: control group 0.31 ± 0.12 μm; 10-year post-PRK group 0.56 ± 0.15 μm; P = 0.141). The main contribution was the increase of spherical aberrations (Z 12) and spherical-like aberrations (S 4), which increased by fourfold and 2.5-fold, respectively, in the 10-year post-PRK group (control group Z 12 0.08 ± 0.11 μm, S 4 0.14 ± 0.05 μm; 10-year post-PRK group Z 12 0.35 ± 0.15 μm, S 4 0.37 ± 0.14 μm; P = 0.010*). Most increases of ocular HOAs induced by corneal refractive surgery are becoming extremely minor at 10 years postoperatively, closer to the corresponding preoperative amount. The largest increase was spherical and spherical-like aberrations, especially with a larger pupil size.