Generalized granulomatous dermatitis accompanied by myelodysplastic syndrome.

Cutaneous manifestations associated with myelodys-plastic syndrome (MDS) are uncommon. Recognizing MDS skin manifestations is important as they can precede blood or bone marrow transformation to leukaemia and are associated with a poor prognosis (1, 2). Recently, 2 cases of granulomatous dermatitis associated with MDS were reported as non-specific cutaneous manifestations of MDS, with subsequent development into acute myeloid leukaemia with leukaemia cutis (1, 2). An imbalance of T-cell subsets, regulatory T cells (Tregs) and Th17 in MDS is also correlated with disease progression (3, 4). We describe here a case of granulomatous dermatitis accompanied by MDS, which we hypothesized might show correlations with Tregs and interleukin (IL)-17 producing cells. We therefore employed immunohisto-chemical staining for Foxp3 and IL-17 to characterize the granuloma.CASe RepoRT