Sucralfate does not reduce the risk of acid aspiration pneumonitis

Objective: To study the pulmonary effects of aspirating a mixture of sucralfate in water and sucralfate in hydrochloric acid in an animal model of aspiration pneumonia. Design: Prospective, randomized, controlled study with repeated measures. Setting: University research laboratory. Subjects: Thirty-two in situ, isolated, blood perfussed porcine lung preparations. Interventions: Five control preparations receivedno aspiration. Twenty-seven preparations received a standard aspiration of 1.5 mL/kg body of a) distilled water (n=5), b) sucralfate in distilled water (n=8), c) 1/10 normal hydrochloric acid (n=6), and d) mixture of sucralfate in distilled water and hydrochloric acid (n=8)