Transposon mutagenesis identifies genetic drivers of Braf V600E melanoma

Michael B. Mann,Michael A. Black,Devin J. Jones,Jerrold M. Ward,Christopher Chin Kuan Yew,Justin Y. Newberg,Adam J. Dupuy,Alistair G. Rust,Marcus Bosenberg,Martin McMahon,Cristin G. Print,Neal G. Copeland,Nancy A. Jenkins

Transposon mutagenesis identifies genetic drivers of Braf V600E melanoma

2015

Michael B. Mann
Michael A. Black
Devin J. Jones
Jerrold M. Ward
Christopher Chin Kuan Yew
Justin Y. Newberg
Adam J. Dupuy
Alistair G. Rust
Marcus Bosenberg
Martin McMahon
Cristin G. Print
Neal G. Copeland
Nancy A. Jenkins

Nancy Jenkins, Neal Copeland and colleagues report the results of a Sleeping Beauty transposon mutagenesis screen in mice carrying a melanocyte-specific inducible BrafV600E allele. Analysis of transposon insertion sites identified candidate genetic drivers of melanoma.

Keywords:

Melanoma
Exome
Mutagenesis
Transposable element
Sleeping Beauty transposon system
Transposon mutagenesis
Genetics
Allele frequency
Allele
Biology

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