Abstract 9943: Prevention and Reversal of Hypertrophy Through a Novel Drug-Like Compound That Inhibits Local Calcium Oscillations in a Pmca4/calcineurin Microdomain

Tamer M.A. Mohamed,Delvac Oceandy,Riham Abou-Leisa,Min Zi,Sukhpal Prehar,Florence Baudoin-Stanley,Elizabeth J. Cartwright,Ludwig Neyses

Abstract 9943: Prevention and Reversal of Hypertrophy Through a Novel Drug-Like Compound That Inhibits Local Calcium Oscillations in a Pmca4/calcineurin Microdomain

2011

Tamer M.A. Mohamed
Delvac Oceandy
Riham Abou-Leisa
Min Zi
Sukhpal Prehar
Florence Baudoin-Stanley
Elizabeth J. Cartwright
Ludwig Neyses

In pathological hypertrophy, the calcium/calmodulin dependent phosphatase calcineurin has been shown to transmit upstream calcium signals through dephosphorylation of the transcription factor NFAT ...

Keywords:

Calcineurin
Calcium
Lipid microdomain
Cardiology
Endocrinology
Internal medicine
Medicine
Muscle hypertrophy
Cell biology
Phosphatase
Dephosphorylation
Transcription factor
Calmodulin
NFAT

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