Результаты токсикологического исследования изопропилметакарборана при его многократном (хроническом) поступлении в организм лабораторных животных

The results of a toxicological study of isopropyl meta-carborane with its repeated (chronic) administration to rats, mainly in the form of inhalations, are presented for the first time to fill in the missing information on the toxicology of carboranes that have found wide application in various fields of human economic activity. The aim of the study was to identify the characteristic features of the organism's response to repeated exposure to the substance, as well as the possible specificity inherent in boron compounds. Methods. Along with numerous typical methods of preventive toxicology (physiological, hematological, biochemical, morphological), the methods for evaluation of possible mutagenic (dominant lethal mutations, chromosomal aberrations) of gonadotoxic and embryotoxic effects were used. Statistical processing of data was carried out using the programs "Microsoft Office Excel 2007" and "Biostat". Differences were considered statistically significant at p 3 .