Effect of High Dietary Fat on Insulin Secretion in Genetically Diabetic Goto-Kakizaki Rats

Wenbin Shang,Koichiro Yasuda,Akira Takahashi,Akihiro Hamasaki,Mihoko Takehiro,Koichiro Nabe,Heying Zhou,Rei Naito,Hideya Fujiwara,Dai Shimono,Hiroyuki Ueno,Hiroki Ikeda,Kentaro Toyoda,Yuichiro Yamada,Takeshi Kurose

Effect of High Dietary Fat on Insulin Secretion in Genetically Diabetic Goto-Kakizaki Rats

2002

Wenbin Shang
Koichiro Yasuda
Akira Takahashi
Akihiro Hamasaki
Mihoko Takehiro
Koichiro Nabe
Heying Zhou
Rei Naito
Hideya Fujiwara
Dai Shimono
Hiroyuki Ueno
Hiroki Ikeda
Kentaro Toyoda
Yuichiro Yamada
Takeshi Kurose

Introduction and AimTo clarify the effects of a high fat-diet on insulin secretion from genetically diabetic beta cells, Goto-Kakizaki rats and Wistar rats were subjected to oral glucose tolerance test (OGTT) after 12-week high-fat feeding.MethodologyWe compared Wistar and Goto-Kakizaki (GK) rats fe

Keywords:

Insulin
Internal medicine
Endocrinology
Secretion
Autoimmune disease
Glucose tolerance test
Lipotoxicity
Diabetes mellitus
Beta (finance)
Biology
Immunopathology
goto kakizaki
insulin secretion
oral glucose tolerance
dietary fat

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