Effect of Curcumin on sFlt-1 and PlGF Concentration in Preeclampsia Induced HUVEC Cell Line

Preeclampsia is a multisystem disorder characterized by hypertension and proteinuria. Elevated soluble fms-like tyrosine kinase 1 (sFlt-1) and reduced placental growth factor (PlGF) levels are documented in preeclampsia patients. Oxidative stress is known to play a role in the etiopathogenesis of preeclampsia. Hence, antioxidants as physiological protective agents can be used in the treating preeclampsia. In this study, we assessed the antioxidant properties of curcumin in HUVEC cell line cultured in serums collected from normal and preeclamptic pregnant women. The levels of sFlt-1 and PlGF were measured with ELISA. We found that sFlt-1 level and sFlt-1/PlGF ratio decreased significantly (p