Synthesis, antitumor activity, and molecular docking of (−)-epigallocatechin-3-gallate-4β-triazolopodophyllotoxin conjugates

Cheng-Ting Zi,Liu Yang,Yue Hu,Pan Zhang,Han Tang,Bang-Lei Zhang,Xiao-Jing Shen,Qing-Hua Kong,Ya Wang,Xuanjun Wang,Jun Sheng

Synthesis, antitumor activity, and molecular docking of (−)-epigallocatechin-3-gallate-4β-triazolopodophyllotoxin conjugates

2020

Cheng-Ting Zi
Liu Yang
Yue Hu
Pan Zhang
Han Tang
Bang-Lei Zhang
Xiao-Jing Shen
Qing-Hua Kong
Ya Wang
Xuanjun Wang
Jun Sheng

Two new (−)-epigallocatechin-3-gallate-4β-triazolopodophyllotoxin conjugates (7 and 8) were synthesized and evaluated for biological activity. Compound 8 showed highly potent anticancer activity ag...

Keywords:

antitumor activity
Conjugate
Gallate
Chemistry
Biochemistry
Docking (molecular)
Biological activity
Combinatorial chemistry
Click chemistry

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