Characteristics Based on Molecular Subtypes in Diffuse Large B-Cell Lymphoma Cases

Diffuse B-cell origin large cell lymphoma (DLBCL) is a type of non-Hodgkin's malignant lymphoma most commonly found in adults. Based on the gene or molecular expression profile, DLBCL can be divided into GCB (Germinal Center B-Cell-Like) and ABC / Non-GCB (Activated B-Cell-Like). However, identification of this grouping is still rarely done in Indonesia, especially Makassar City. This study aims to determine the characteristics of DLBCL cases based on molecular examination. This study used a sample of 44 cases of paraffin block for DLBCL patients from 2017 to 2019, then categorized using the Hans algorithm. Of the 44 cases, the number of GCB was 8 cases (18.2%) and ABC / Non-GCB 36 cases (81.8%). The incidence of female sex was slightly lower (47.7%) than in men (52.3%) with the most frequent location being nodal with 36 cases (81.8%) and extranodal as many as 8 cases (18.2%) . Meanwhile, age was found more frequently in patients with age 60 years (12 cases, 27.3%) with a mean age of 52.57 years. The results showed that the ABC / Non-GCB type DLBCL was more common than the GCB type in patients in Makassar city.