EFFECT OF Tamarindus indica Linn. AGAINST ISOLATED GOAT TRACHEAL AND GUINEA PIG ILIUM PREPARATION

According to Ayurveda, Tamarindus indica Linn. (Caesalpiniaceae) is used in the treatment of asthma, inflammation, dysentery, vaginal and uterine complaints and variety of conditions. In the present study methanolic extract of leaves of Tamarindus indica Linn. in the histamine induced dose dependent contraction of goat tracheal chain and guinea pig ileum preparation was significantly inhibited (p< 0.01) by the methanolic extract of leaves of Tamarindus indica Linn. (400 µg/ml and 80 µg/ml). Thus the present study revealed that the methanolic extract of leaves of Tamarindus indica Linn. has significant antihistaminic (H1 receptor antagonist) activity. The Tamarindus indica Linn. by virtue of the said actions will prove to be very effective in the antihistaminic therapy of asthma.