Linfoma primario cutáneo difuso de células B grandes, tipo pierna

El PCLBCL-LT es un trastorno linfoproliferativo infrecuente de mal pronostico, que afecta principalmente ancianos con fuerte predominio en mujeres, caracterizado por nodulos o tumores rojo azulados, solitarios o agrupados en las piernas. El examen histopatologico presenta celulas grandes como centroblastos e inmunoblastos, con fenotipo para linaje B y fuerte expresion para Bcl-2. El tratamiento para lesiones solitarias o poco numerosas consiste en radioterapia, y en casos de compromiso multifocal poliquimioterapia. Comunicamos un caso de una paciente de 74 anos con PCLBCL-LT, con antecedente de leucemia linfocitica cronica (LLC), que consulto por tumores eritematosos de rapida evolucion en las piernas y el brazo izquierdo. Se planteo como diagnostico un linfoma cutaneo primario de celulas B, asi como tambien se establecio diagnostico diferencial con el sindrome de Richter, linfomas cutaneos CD 30 + y leucemia cutis. (Dermatol Argent. 2014; 20 (2): 119-122) Palabras clave: linfoma primario cutaneo, linfoma difuso de celulas B grandes, tipo pierna Primary cutaneous diffuse large B-cell Lymphoma, leg type (PCLBCL-LT) Abstract The PCLBCL-LT is a rare lymphoproliferative disorder with a poor prognosis, mainly affecting elderly people with strong female preponderance, characterized by bluish red nodules or tumors, solitary or grouped in the legs. Histopathologic examination has typically large cells as centroblasts and immunoblasts, with B-lineage phenotype and strong expression for Bcl-2. Treatment for solitary lesions or few in number is radiation therapy, and in multifocal cases chemotherapy. We reported a 74 year old patient with PCLBCL-LT, with a history of chronic lymphocytic leukemia (CLL), consulting for rapidly developing erythematous tumors in the legs and left arm. Diagnosis is proposed as primary cutaneous B-cell lymphoma, as well as establishing a differential diagnosis with Richter’s syndrome, CD30+ cutaneous lymphomas and leukemia cutis. (Dermatol Argent. 2014; 20 (2): 119-122) Keywords: primary cutaneous, lymphoma, diffuse large B-cell lymphoma, leg type.