Rapamycin derivative, preparation method, pharmaceutical composition and uses thereof

The present invention belongs to the field of medicine and chemical industry, and relates to a rapamycin derivative represented by a formula I, a preparation method, a pharmaceutical composition and uses thereof. According to the compound of the present invention, the disadvantages of water solubility and metabolic property of rapamycin are improved, the partial compounds have in vitro antitumor activity superior to rapamycin while have low toxicity on normal cells compared to rapamycin, and the compound has good medicine forming property. The formula I is defined in the specification.