ATROPO-ENANTIOSELECTIVE SYNTHESIS OF A SIMPLIFIED ANALOG OF MASTIGOPHORENES A AND B
1998
Abstract A first approach to the atroposelective total synthesis of mastigophorenes is described, the directed preparation of a structurally slightly modified analog of mastigophorenes A and B, with a tert -butyl instead of a substituted, chiral cyclopentyl residue. Its (partially protected) monomeric half is dimerized by oxidative (phenolic) coupling to give the corresponding biphenyl in a racemic form, or atropo-enantioselectively via the corresponding biaryl lactone, to give the M - or, optionally, the P -enantiomeric form, by stereoselective ring opening and subsequent standard transformations.
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