Neurognese no crebro adulto e na condio epilptica

ABSTRACT Neurogenesis in the adult brain and in epileptic condition Introduction: Since the early XX century, there have been numerous reports considering the possibility ofneurogenesis in the adult mammalian brain. However, it took 30 years before the widespread skepticism andthe technical limitations were overcome. Refined cell technique developments and clear-cut evidences ofneurogenesis in avian and rodent brains boosted additional research and counteracted the “no-new-neuron-in-the-adult-brain” myth. Now, the debate has focused on its importance to existing neural circuits, whichpromises interesting perspectives in medical research. Results: Reactive neurogenesis in the hippocampusoccurs in different experimental models of temporal lobe epilepsy, among them those that present spontaneouslimbic seizures after an episode of status epilepticus . Phylogenetic differences between rodents and humansprobably exist, since it has been described a reduction of neurogenesis in children with severe epilepsy.Neurogenesis may also be altered in many other conditions including chronic antidepressant drug treatment.