Copper‐Catalyzed Highly Efficient Oxidative Amidation of Aldehydes with 2‐Aminopyridines in an Aqueous Micellar System.

An environmentally benign protocol for the synthesis of N-(pyridine-2-yl)amides from aldehydes and 2-aminopyridines has been developed under mild reaction conditions. This approach requires Cu(OTf)2 as a catalyst, and inexpensive molecular iodine as an oxidant under anionic micellar catalysis in aqueous medium at room temperature.