Asymmetric synthesis of cytotoxic sponge metabolites R-strongylodiols A and B and an analogue

Abstract The asymmetric synthesis of the marine sponge natural products R -strongylodiols A R - 1 and B R - 2 , using a minimum protection strategy, is described. Two approaches were examined and the Noyori asymmetric reduction of ynones was found to be successful for installing the chirality of the natural products. Analogue R - 32 was also prepared. In addition, asymmetric alkynylation of aldehydes is briefly reviewed.