Baseline hepatitis C virus resistance-associated substitutions present at frequencies lower than 15% may be clinically significant

Ministerio de Sanidad, Servicios Sociales e Igualdad grant name “Plan Estrategico Nacional contra la Hepatitis C”; Instituto de Salud Carlos III cofinanced by the European Regional Development Fund (ERDF) grant number PI16/00337; and Centro para el Desarrollo Tecnologico Industrial-CDTI from the Spanish Ministry of Economics and Competitiveness (MINECO) grant number IDI-20151125. Work at CSIC-UAM supported by grants SAF2014-52400-R, SAF2017-87846-R from MINECO; S2013/ABI-2906 (PLATESA from Comunidad Autonoma de Madrid/FEDER), and institutional grants from Fundacion Ramon Areces and Banco Santander