Correlation of metabolic syndrome with neutrophils-lymphocytes ratio, platelet-lymphocyte ratio and white blood cell count in the elderly

Objective To analyze and compare the correlation of neutrophils-lymphocytes ratio(NLR), platelet-lymphocyte ratio(PLR)and white blood cell count with metabolic syndrome(MS)in the elderly. Methods A total of 2, 322 people aged 65 years and over who took physical examination in health medical center of our hospital in 2010 were selected. The general information, waist circumference, height, weight, blood pressure were collected. Routine blood cell test, blood glucose, insulin, blood lipids, liver and kidney function were detected. Then, body mass index(BMI), NLR, PLR, homeostasis model assessment of insulin resistance(HOMA- IR), HOMA-β cells(HOMA-β)were calculated. According to the MS definition of Chinese adult dyslipidemia prevention guide(2007), all participants were divided into two groups: MS group and non-MS group. The relevant indices were compared between two groups. Results NLR had no significant difference between MS and non-MS groups〔1.7(1.3, 2.2)vs. 1.7(1.3, 2.2), P=0.273〕. PLR was lower in MS group than in non-MS group〔84.0(67.0, 105.7)vs. 89.0(67.2, 112.0), P=0.006〕, and PLR showed a significantly decreasing trend in MS group along with the increase of abnormal metabolic component numbers(P 0.05). HOMA-IR showed a significantly decreasing trend in the three subgroups which was divided by tertiles of PLR(P<0.05). While HOMA-IR showed a significantly increasing trend in the three subgroups which was divided by tertiles of white blood cells(P<0.05). Logistic regression analysis showed that the white blood cells was the independent risk factors for the occurrence and the severity of MS〔OR=1.24(1.15~1.33); MS2: OR =1.12(1.01~1.24)and MS3: OR=1.40(1.04~1.89)〕. Conclusions The white blood cells is superior to the NLR and PLR as a predictive factor for the presence and severity of MS in the elderly. Key words: Metabolic syndrome X; Blood cell count; White blood cells