Synthesis and biological evaluation of ternary silver compounds bearing N,N-chelating ligands and thiourea: X-ray structure of [{Ag(bpy)(μ-tu)}2](NO3)2 (bpy = 2,2′-bipyridine; tu = thiourea)

Abstract Compounds [{Ag(phen)(μ-tu)} 2 ](NO 3 ) 2 ( 1 ), [{Ag(phen)(μ-tu)} 2 ](CF 3 SO 3 ) 2 ( 2 ), [{Ag(bpy)(μ-tu)} 2 ](NO 3 ) 2 ( 3 ) (where phen = 1,10-phenanthroline; bpy = 2,2′-bipyridine; tu = thiourea) were prepared by reacting the appropriate AgX salt (X −  = NO 3 − , CF 3 SO 3 − ), the N , N -chelating ligand (phen or bpy) and thiourea in a ca. 1:1:2 M ratio, respectively. The silver(I) complexes were characterized by elemental analysis, infrared (IR), 1 H and 13 C NMR spectroscopies, MS/ESI and conductivity measurements. The IR and NMR data were consistent with the presence of chelating phen ( 1 and 2 ) and bpy ( 3 ) ligands and demonstrated the S -coordination mode of thiourea. The crystal and molecular structures of compound [{Ag(bpy)(μ-tu)} 2 ](NO 3 ) 2 ( 3 ) were determined by single-crystal X-ray diffraction. The complexes 1 – 3 were screened for their in vitro antimycobacterial ( Mycobacterium tuberculosis ), antileishmanial ( Leishmania ( L. ) amazonensis ), antibacterial ( Staphylococcus aureus, Escherichia coli , Pseudomonas aeruginosa ), antifungal activities ( Candida albicans, Candida tropicalis, Candida krusei ).