Synthesis of Some Novel Imidazol-5-one Derivatives and their In-vitro screening for Non-Nucleoside Reverse Transcriptase Inhibitors.

A novel series of 4-substituted ethylidene/benzylidene-2-methyl-1-(pyrimidine-2-yl)-1H-imidazol-5one derivatives were efficiently synthesized. The synthesized compounds were evaluated for their in-vitro reverse transcriptase inhibition activity using reverse transcriptase colorimetric assay kit (Roche). Some of these compounds showed significant reverse transcriptase inhibitory activity. Docking study was performed to study the binding orientation and affinity of synthesized compounds for RT enzyme.