Pupillary light reflex in panic disorder. A trial using audiovisual stimulation.
2004
Although many previous studies
reported abnormalities of autonomic function in patients
with panic disorder (PD), almost all targets in
those studies primarily focused on cardiovascular autonomic
functions. In the present study, we determined
whether PD patients exhibited abnormalities in the
pupillary autonomic nervous system (ANS). Before and after audiovisual stimulation (AS), which induced
mental stress through exposure to video images
of high stress experiences, such as driving motor vehicles,
the pupillary light reflex (PLR) was measured by infrared
pupillometer in 13 remitted PD patients and
twenty age– and gender–matched normal controls (NC). Before and after AS, there were no significant differences
in initial pupillary diameters in dark conditions
(D1), pupillary diameters at maximum constriction
(D2) or constriction ratios (CR: (D1-D2)/D1)
between PD and NC subjects. However, the CR ratio (CR
before/CR after) was significantly higher in the PD
group than in the NC. These findings suggest
that even remitted PD patients may have a dysfunctional
PLR regulation with experimental stressors such
as AS.
Keywords:
- Correction
- Source
- Cite
- Save
- Machine Reading By IdeaReader
14
References
18
Citations
NaN
KQI