Antitumor effects of human recombinant interferon-γ and tumor necrosis factor on five cervical adenocarcinoma cell lines, in vivo and in vitro

Abstract We examined the antitumor effects of recombinant interferonγ (IFN-γ) and tumor necrosis factor (TNF) on cervical adenocarcinoma cell lines, in vitro and in vivo . Four of five cell lines showed a high sensitivity to IFN-γ, in vitro . One of five cell lines showed a remarkable sensitivity to TNF, in vitro . Only one cell line resistant to both IFN and TNF was derived from a welldifferentiated adenocarcinoma of endocervical type. Experiments using nude mice bearing transplanted tumors revealed that these cytokines were also effective against tumors in vivo . All these observations suggest that IFN-γ or TNF can have positive effects in the treatment of patients with adenocarcinoma of the uterine cervix.