Quantitative and temporal requirements revealed for Zap70 catalytic activity during T cell development

Byron B. Au-Yeung,Heather J. Melichar,Jenny O. Ross,Debra A. Cheng,Julie Zikherman,Kevan M. Shokat,Ellen A. Robey,Arthur Weiss

Quantitative and temporal requirements revealed for Zap70 catalytic activity during T cell development

2014

Byron B. Au-Yeung
Heather J. Melichar
Jenny O. Ross
Debra A. Cheng
Julie Zikherman
Kevan M. Shokat
Ellen A. Robey
Arthur Weiss

TCR ligation activates the kinase Zap70. Weiss and colleagues, utilizing 'analog-sensitive' Zap70 cells, show that thymocyte positive and negative selection exhibit differential temporal requirements for Zap70 signaling.

Keywords:

Cell biology
Immunology
Lymphopoiesis
Cellular differentiation
T-cell receptor
Signal transduction
T cell
Biology
Negative selection
Thymocyte
ZAP70

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