Bacterial DNA and CpG--Containing Oligodeoxynucleotides Activate Cutaneous Dendritic Cells and Induce IL--12 Production: Implications for the Augmentation of Th1 Responses

Thilo Jakob,Patricia S. Walker,Arthur M. Krieg,Esther von Stebut,Mark C. Udey,Jonathan C. Vogel

Bacterial DNA and CpG--Containing Oligodeoxynucleotides Activate Cutaneous Dendritic Cells and Induce IL--12 Production: Implications for the Augmentation of Th1 Responses

1999

Thilo Jakob
Patricia S. Walker
Arthur M. Krieg
Esther von Stebut
Mark C. Udey
Jonathan C. Vogel

Background: Unmethylated CpG sequences in bacterial DNA act as adjuvants selectively inducing Th1 predominant immune responses during genetic vaccination or when used in conjunction

Keywords:

Immunology
Virology
Dendritic cell
Immune system
MHC class II
CpG site
Adjuvant
DNA
Interleukin 12
Biology
In vitro
Langerhans cell

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