Glycemic Effect of Freeze Dried Murraya Koenigii - An Evidence Based Study

The scientific evaluation of hypoglycemic and antid iabetic activity of freeze dried leaves of Murraya koenigii was carried out in normal and Streptozotocin-induc ed sub- and mild- diabetic rats. A single oral administration of variable doses of 100, 200, 300 a nd 400 mg kg -1 lowered Blood Glucose Level in normal and diabetic rats. A fall of 41.5% in normal , 34.3% in sub-diabetic and 37.9% in mild-diabetic rats was observed with the dose of 300 mg kg -1 after 6 h of oral administration. Same dose also improved glucose tolerance as indicative from the f all of 38.7% in normal, 54.3% in sub-diabetic and 51.7% in mild-diabetic rats in Glucose Tolerance Te st after 3 h. The findings of glycemic and phytochemical studies suggest that the identified p hytochemicals might be responsible for its glycemic effect and hence, the freeze dried powder may be pr escribed as adjunct to dietary therapy and drug treatment for managing diabetes mellitus.