Serum Ang and CysC Levels in Essential Hypertension Complicated by Hypertensive Emergencies.

OBJECTIVE To explore the value of serum angiotensin Ⅱ (Ang II) and cystatin C (CysC) levels in predicting hypertension emergency in patients with essential hypertension. STUDY DESIGN Experimental study. PLACE AND DURATION OF STUDY  Hangzhou Hospital of Zhejiang Medical and Health Group, from January 2018 to February 2020. METHODOLOGY  One hundred and thirty seven patients with essential hypertension were divided into hypertension emergency group (Group A, 42 cases) and essential hypertension group without emergency (Group B, 95 cases).  Ninety-five healthy subjects were selected as control group. Correlation between serum Ang and CysC and essential hypertension complicated with hypertension emergency was analysed. Diagnostic ability of Ang and CysC was analysed by ROC curve. RESULTS Serum Ang and CysC levels in Group A and B were higher than those in control group (all p <0.001); serum Ang II and CysC levels in Group A were higher than those in Group B (both p <0.001). Serum Ang II and CysC levels were positively correlated with essential hypertension complicated with hypertension emergency (r=0.480, p <0.001; r=0.485,p <0.001, respectively). Area under ROC curve of serum Ang II combined with CysC for predicting hypertension emergency was 0.905 (95%CI: 0.854-0.955), which was larger than that of serum Ang II, CysC  alone. CONCLUSION Serum Ang II and CysC in patients with primary hyperemia complicated with hypertension emergency were higher. Combined detection of serum Ang II and CysC might be used as an effective reference index for predicting hypertension emergencies in patients with essential hypertension. Key Words: Serum, Angiotensin Ⅱ (Ang II), Cystatin C (CysC), Essential hypertension, Hypertension emergency.