Preparation and cell growth inhibitory activity of [PtR2L2] (R = polyfluorophenyl, L2 = diene, cyclohexane-1,2-diamine (chxn) or cis-(dimethyl sulfoxide)2) and the X-ray crystal structure of [Pt(C6F5)2(cis-chxn)]

Abstract A range of [PtR 2 (chxn)] (R=C 6 F 5 , o -HC 6 F 4 , p -HC 6 F 4 , p -MeOC 6 F 4 or 3,5-H 2 C 6 F 3 ; chxn=cyclohexane-1,2-diamine) and cis -[PtR 2 (dmso) 2 ] (R=C 6 F 5 , p -HC 6 F 4 or p -MeOC 6 F 4 ; dmso=dimethyl sulfoxide) complexes have been prepared from the corresponding [PtR 2 (diene)] (diene= cis,cis -cycloocta-1,5-diene (cod), hexa-1,5-diene (hex), norbornadiene (nbd) or dicyclopentadiene (dcy)) derivatives and have been spectroscopically characterized. A representative crystal structure of [Pt(C 6 F 5 ) 2 ( cis -chxn)] was determined and shows a slightly distorted square planar geometry for platinum with chxn virtually perpendicular to the coordination plane. The biological activity against L1210 and L1210/DDP cell lines of these compounds together with the behaviour of other organoplatinum complexes, [PtR 2 L 2 ] (L 2 =ethane-1,2-diamine (en) or cis -(NH 3 ) 2 ) have been determined. Despite the use of relatively inert fluorocarbon anions as leaving groups, moderate–high cell growth inhibitory activity is observed. None of the fluorocarbon complexes displayed any cross resistance with cisplatin.