Chronic Obstructive Pulmonary Disease: Pulmonary Function and CT Lung Attenuation Do Not Show Linear Correlation

A multiple model estimation approach that combines measurements of airflow obstruction (forced expiratory volume in 1 second/vital capacity), overinflation (percentage functional residual capacity), and parenchymal destruction (diffusing capacity of lung for carbon monoxide) predicts accurately the inspiratory and expiratory percentage area with CT attenuation values less than −950 HU over a wide range of values.