Association of Matrilin-3 and Adiponectin Polymorphisms with Susceptibility to Knee Osteoarthritis

Background: The associations of Matrilin-3 (MATN3) and Adiponectin (ADIPOQ) polymorphisms with knee osteoarthritis (OA) risk have been reported, but it is currently the conclusions have been divergent. Methods: We carried out this case-control study involving 105 cases with knee OA and 120 healthy subjects to evaluate the association of MATN3 rs8176070, ADIPOQ rs1501299, rs822396, and rs2241766 polymorphisms with knee OA using RFLP-PCR assay. Results: There was a significant association between MATN3 rs8176070 polymorphism and KOA risk. However, there was no significant association between rs1501299, rs822396, and rs2241766 polymorphisms at ADIPOQ gene and knee OA risk. Conclusions: These pieces of evidence revealed that MATN3 polymorphism was serving as risk factor for development of knee OA, but not ADIPOQ rs1501299, rs822396, and rs2241766 polymorphisms. However, well-designed and large-scale clinical studies are necessary to further validate our results. Funding: This work was supported by Tehran North Branch, Islamic Azad University, Tehran, Iran. Declaration of Interests: The authors declared no potential conflicts of interest with respect to the research or publication of this article. Ethics Approval Statement: The local ethics committee approved the protocol in accordance with the Helsinki declaration and national guidelines, every woman enrolled in this study signed a consent form.