Sickle‐cell disease in sub‐Saharan Africa

Background and Objectives Sickle-cell disease, over a century since its discovery, remains a great challenge in sub-Saharan Africa, where the burden of the disease is highest and where resources for managing its various complications are scarce. This paper is a general review of sickle-cell disease and, especially in Africa, focusing on its manifestations, complications and the management strategies in place. Materials and Methods Data for this review were collected from published articles, books, and internet websites and from personal experiences. Results The findings highlight the major clinical manifestations, the diagnostic methods and management strategies used in sub-Saharan Africa as well as some of the challenges encountered. Conclusions Better organisation with co-ordinated multidisciplinary teams as well as government commitment is indispensable for optimal sickle-cell disease care in sub-Saharan Africa.