Polimorfismo no gene IL-10 (-627) em idosos portadores de doença periodontal IL-10 gene polymorphism in elderly with periodontal disease

Introduction: Genetic factors contribute to the risk of periodontal disease (PD) in the elderly. Objective: � his study aimed to evaluate the association beteen peri- � his study aimed to evaluate the association beteen peri- odontal disease and interleukin-10 gene polymorphism in 66 elderly. Methods: PDas diagnosed using the index PIP. � he genetic polymorphismas analyzed by polymerase chain reaction folloed by cleavageith restriction enzyme Rsa I. Results: � he study included 66 elderly (mean age: 68 ± 5.02 years), 63.3% female gender and 36.4% male. � he elderly harboring AA genotype or A alleleere sig- � he elderly harboring AA genotype or A alleleere sig- nificantly associatedith severe PD, according to c2 test (p<0.05), suggesting that this genotype or allele may be a genetic factor leading to chronic susceptibi- lity of PD. Conclusions: � he genetic polymorphism at position -627 of the IL-10 gene may influence the PD severity in the elderly.