Juvenile metachromatic leukodystrophy: neurological outcome two years after bone marrow transplantation

Our patient was not an ideal candidate since she was not clinically completely asymptomatic and presented with abnormal MRI and decreased nerve conduction when the metachromatic leukodystrophy was diagnosed in her older sibling. Nevertheless, 2 years after graft the deterioration did not progress and the MRI improved, while her brother became bed-ridden within few months after the same initial symptoms.