Expression of survivin and phosphatase and tensin homolog deleted on chromosome ten and their correlations in hepatoceilular carcinoma

Objective To study the expression of survivin and phosphatase and tensin homolog de- leted on chromosome ten （PTEN） mRNA and protein and their correlations with clinicopatholocal factors of hepatocellular carcinoma （HCC）. Methods Reverse transcriptase-polymerase chain reaction （RT-PCR） and immunohistochemistry were used to detect the expression of Survivin and PTEN mRNA and protein in 32 cases of HCC and their adjacent noncancerous tissues. Results The expression rate of survivin mRNA in HCC tissues and their adjacent noncancerous tissues was 68.75% and 3.13% respectively, and that of PTEN was 43.75% and 87.50% respectively. The high expression of survivin and the low expression of PTEN were positively corelated with the pathological grading, diameter of caicinoma and vein micro-metas- tasis in HCC （ P 〈 0. 05）. The expression of survivin showed a negative corelation with PTEN expression in HCC （P 〈 0. 05）. Conclusion These data show a corelation between survivin and PTEN expression and invasion and metastasis in HCC. Key words: Carcinoma, hepatocellular;  Survivin;  Phosphatase and tensin homolog deleted on chromosome ten