Dose-Dependent Effects of Corticosterone on Leydig Cell LH Receptors and Steroidogenesis In vitro

Glucocorticoid excess due to stress, endocrine disorders or therapeutic application has been recognized to have an adverse efTect on androgenic status of men. Our previous studies emphasized the defective LH signal transduction in Leydig cells exposed to corticosterone. The present study was designed to identify the dose-dependent effects of corticosterone on the regulation of Leydig cell surface LH receptors and steroidogenic potency in vitro .