Effects of topical Dry Nose Spray on the transepithelial water loss and potential difference in human nasal mucosa

BACKGROUND: Nasal airway is the entrance to the respiratory tract. The upper airway has function of humidification and secretion. We have already demonstrated the human nasal mucosal water loss as the transepithelial water loss. The aim of this study is to evaluate the short term effect of DryNose TM Spray on the transepithelial loss and alteration of potential difference (PD) in human nasal mucosa. METHODS: Measurement of transepithelial water loss of nasal mucosa (TEWL) was performed on the inferior nasal turbinate by using Tewamerter TM210 (Courage + Khasaka electric, Germany). PD was measured using the Ussing's technique. RESULTS: The significant decrease in TEWL was observed after spray. On the other hands, PD did not change after spray. CONCLUSION: The effects of topical application of DryNose Spray on nasal mucosa decreased water loss.