Renal Function in Primary Hyperparathyroidism: A Follow-up Study Two to Eleven Years after Surgery Comprising 139 Patients

Out of 160 consecutive patients operated upon for primary hyperparathyroidism, a follow-up study on renal function could be performed in 139. Clearances of inulin (CIN) and paraaminohippurate (CPAH) were determined before and after surgery in 75 of the patients. The average length of postoperative observation was 4.8 years (range 2-11 years) in this group. On average, CIN and CPAH were well maintained at the follow-up compared to the preoperative findings. This was true even for the group of patients with abnormal renal function before surgery. Only in two patients was an unequivocal decrease of CIN demonstrated. In two other subjects, however, serum creatinine showed an increase in the face of equivocal changes in CIN and CPAH.In 64 patients kidney function was evaluated only from the serum creatinine level. The average postoperative period of observation was 5.4 years (range 2-9 years). Renal function had deteriorated in two patients, one of whom suffered from chronic nephritis. Among 13 deceased patien...