The preparation method of 3 isobutylglutaric acid monoamides

The present invention relates to the preparation method of a kind of 3 isobutylglutaric acid monoamides, product can comprise the steps of raw material isovaleral as pregabalin intermediate and Malonamide nitrile. generate condensation substance by catalyzing and condensing in a mild condition；This condensation substance hydrolyzes generation 3 isobutylglutaric acids in acid condition；3 isobutylglutaric acid acid anhydrides are generated by anhydridization reaction；End product 3 isobutylglutaric acid monoamides is generated through amidation.The present invention passes through base catalyst catalyzing and condensing, is effectively improved condensation reaction efficiency, and product yield is high, by-product is few, and reaction condition is gentle, and the process of the beneficially three wastes, provide an environmental protection for industrialized great production, be operation safety, high yield, low cost, a route for environmental protection.