Determination of apatinib and its three active metabolites by UPLC-MS/MS in a Phase IV clinical trial in NSCLC patients.

Shaoxing Guan,Wei Shi,Ze-Rui Zhao,Fei Wang,Fulin Jiang,Caibin Zhang,Zhongming Jin,Yanping Guan,Di-Han Liu,Guoping Zhong,Min Huang,Hao Long,Xueding Wang

Determination of apatinib and its three active metabolites by UPLC-MS/MS in a Phase IV clinical trial in NSCLC patients.

2019

Shaoxing Guan
Wei Shi
Ze-Rui Zhao
Fei Wang
Fulin Jiang
Caibin Zhang
Zhongming Jin
Yanping Guan
Di-Han Liu
Guoping Zhong
Min Huang
Hao Long
Xueding Wang

Aim: To develop and validate a simple method using UPLC–MS/MS for determination of apatinib and its three active metabolites in a Phase IV clinical trial. Materials & methods: All compounds were se...

Keywords:

Chromatography
Active metabolite
High-performance liquid chromatography
Therapeutic drug monitoring
Apatinib
Chemistry
Clinical trial
uplc ms ms

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