Potent achiral agonists of the growth hormone secretagogue (ghrelin) receptor. Part 2: Lead optimisation.

Jason Witherington,Lee Abberley,Michael A. Briggs,Katharine L. Collis,David Kenneth Dean,Alessandra Gaiba,N. Paul King,Helmut Kraus,Nicola Shuker,Jon Graham Anthony Steadman,Andrew K. Takle,Gareth J. Sanger,Graham Wadsworth,Sharon Butler,Fiona McKay,Alison Muir,Kim Winborn,Tom D. Heightman

Potent achiral agonists of the growth hormone secretagogue (ghrelin) receptor. Part 2: Lead optimisation.

2008

Jason Witherington
Lee Abberley
Michael A. Briggs
Katharine L. Collis
David Kenneth Dean
Alessandra Gaiba
N. Paul King
Helmut Kraus
Nicola Shuker
Jon Graham Anthony Steadman
Andrew K. Takle
Gareth J. Sanger
Graham Wadsworth
Sharon Butler
Fiona McKay
Alison Muir
Kim Winborn
Tom D. Heightman

A series of small molecule orally bioavailable ghrelin receptor agonists have been identified through systematic optimisation of a high throughput screening hit.

Keywords:

Ghrelin
Small molecule
Oral administration
Agonist
Growth hormone secretagogue
Biochemistry
High-throughput screening
Endocrinology
Receptor
Chemistry
Peptide hormone
Internal medicine

Correction
Source
Cite
Save
Machine Reading By IdeaReader

References

Citations