MicroRNA-21 targets the vitamin D-dependent antimicrobial pathway in leprosy.

Philip T. Liu,Matthew Wheelwright,Rosane M. B. Teles,Evangelia Komisopoulou,Kristina Edfeldt,Benjamin G Ferguson,Manali Mehta,Aria Vazirnia,Thomas H. Rea,Euzenir Nunes Sarno,Thomas G. Graeber,Robert L. Modlin

MicroRNA-21 targets the vitamin D-dependent antimicrobial pathway in leprosy.

2012

Philip T. Liu
Matthew Wheelwright
Rosane M. B. Teles
Evangelia Komisopoulou
Kristina Edfeldt
Benjamin G Ferguson
Manali Mehta
Aria Vazirnia
Thomas H. Rea
Euzenir Nunes Sarno
Thomas G. Graeber
Robert L. Modlin

The ability of Mycobacterium leprae to upregulate miRNA-21 provides an effective mechanism for the pathogen to escape from the vitamin D–dependent antimicrobial pathway.

Keywords:

Immunology
Virology
Vitamin D and neurology
Immune system
Pathogen
microRNA
Vitamin
Beta defensin
Biology
Mycobacterium leprae
Antimicrobial
Antimicrobial peptides
Gene knockdown
TLR2
Interleukin 10
Antigenic variation

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