Effect of analogs of cinanserin on human lymphocytes in vitro
1973
Cinanserin, 2′-(3-dimethylaminopropylthio)cinnamanilide, was compared in phytohemagglutinin (PHA)-treated human lymphocytes in vitro to two analogs, 2′-(3-dimethylaminopropoxy)-5′-methylcinnamanilide (SQ 11,276) and 5′-tert.-butyl-2′-(3-dimethylaminopropoxy) cinnamanilide (SQ 11,332). These analogs, like cinanserin, exhibit immunosuppressive activity but, unlike cinanserin, possess low antiserotonin activity.
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