Inhibition of Herpes Proteases and Antiviral Activity of 2-Substituted Thieno[2,3-d]oxazinones.
2010
Cinnamyl derivatives of thieno[2,3-d]oxazinones are mechanism-based inhibitors of the HSV-2, VZV and CMV herpes proteases which demonstrate nanomolar potency. Compounds 5 and 28 inhibit protease processing in HSV-2 infected cells with a selectivity index of at least 30.
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