Feasibility of transendocardial injection using multifunctional intracardiac catheter

Objective To investigate the feasibility and safety of transendocardial Evan's blue injection in canine using a self-developed multifunctional intracardiac catheter.Methods Twelve mongrel canines were randomly divided into three groups.Under the mode of echocardiography,the catheter was delivered into the left ventricle.Under the intracardiac ultrasound mode,0.4 ml,0.8 ml or 1.2 ml Evan's blue were sequentially injected into the left ventricular anterior wall and the interventricular septum.Electrocardiographic recordings were obtained during the whole procedure.Three hours after injection,animals were sacrificed and the hearts were harvested.The size of stained myocardial was evaluated.Results Under the guidance of echocardiography,the catheter was inserted to the ventricle.The catheter provided the structural information and guided proper needle position within the target myocardium.There were significant differences in the size of stained myocardial produced by injection of different amounts of Evan's blue infusion,but no significant differences in the size of stained myocardial by injection of the same amounts of Evan's blue infusion was found in the left ventricular anterior wall and the interventricular septum.Conclusion These multifunctional intracardiac catheter system integrated with echocardiography meets the requirements of primary design,may provide a safe and effective way for transendocardial injection in future.