Reply to the letter by Beyan et al "Plateletcrit may not be an index for predicting of liver fibrosis in patients with chronic hepatitis B".

We thank BeyanC and Beyan E for their interest in our study and appreciate their comments(1,2) .We agree that many factors may impact the reliability of plateletcrit (PCT) values. The data was retrospectively collected and the patients were included in a very broad time period. Thus,we also agree that some bias may exist in our study.However, to minimize the bias, we divided our patients into a derivation cohort and a validation cohort by a computer-generated randomization schedule. Byunivariate analysis and multivariate logistic regression analysis, the PCT was identified as an independent factor for significant fibrosisin the derivation cohort(2) .