The −22c/t polymorphism in presenilin 1 gene is not connected with late-onset and early-onset familial Alzheimer’s disease in Poland

The −22c/t polymorphism in the promoter of the presenilin 1 gene is associated with increased risk for Alzheimer’s disease (AD) in some populations. It was shown that −22c allele is connected with two-fold decrease in promoter activity. We studied the impact of the polymorphism in groups of Polish late-onset and early-onset AD patients. Our results suggest that −22c/t polymorphism is not connected with AD in Polish population. The −22t allele showed a high degree of linkage disequilibrium with −2797 insertion of 13 bp. An additional −2923g/t polymorphism is also not connected with −22c/t and is not a risk factor for AD.