Blood coagulation activities in chronic liver diseases

Blood coagulation activities were measured with Hepaplastintest in patients with various chronic liver diseases: 21 cirrhosis of the liver, 33 chronic hepatitis and 24 miscellaneous liver diseases. In chronic liver diseases, HPT values decreased following the degree of hepatic injury. The mean value of HPT were 69. 38±12. 12% in chronic inactive hepatitis, 54.38±9.60% in chronic active hepatitis and 54.02±11.77% in liver cirrhosis.We were compared the value of HPT in each group of liver diseases classified laparoscopically, and the mean value of HPT were 71.5% in smooth liver group and 60.73% in coarsely irregular liver group, but tended to low in nodular liver group (50% or below).Then, the value of HPT was compared with other liver function tests and blood coagulation and clotting tests. And there was a negative correlation between HPT and retention rate of ICG (15′) (r=-0.6117, p<0.001), and also a correlation was recognized between HPT and blood platelets (r=0.5417, p<0.001).But no correlation could be demonstrated between HPT and serum transaminase activity.In conclution, HPT is a sensitive diagnostic test for mild hepatic impairement.