Aggregation of phthalocyanine derivatives in liquid solutions and human blood

Abstract The aggregation of the copper (II) 4,4′,4′′,4′′′-tetrasulfonated phthalocyanine anion (Cu(tsPc) −4 ) has been studied in aqueous solutions, DMSO and in human blood by UV–VIS absorption spectroscopy and resonance Raman spectroscopy (RRS). The vibrational mode ν 4 (1530 cm −1 ) has been used as a probe in RRS. It has been shown that the dimerization equilibrium constant K is shifted significantly towards monomeric forms when human blood is added to the solution. The life-time of the singlet excited state S n of (Cu(tsPc) −4 ) in aqueous solution has been estimated to be shorter than 500 fs using femtosecond pump-probe absorption spectroscopy.