Soy whey based medium for optimized phytase activityin Saccharomyces cerevisiae MTCC 5421 and α-D-galactosidaseand antibacterial activities in Lactobacillus plantarum MTCC5422 by response surface methodology

BACKGROUND: In the present study, the composition of mango peel powder (MPP) collected fromthe mango pulp industrywas determined and the effect ofMPP on ameliorating diabetes and its associated complications was studied. RESULTS: Mango peel was rich in polyphenols, carotenoids and dietary fibre. Peel extract contained various bioactive compounds and was found to be rich in soluble dietary fibre. Peel extract exhibited antioxidant properties and protected against DNA damage. Therefore, the effect of peel on ameliorating diabetes was investigated in a rat model of diabetes. A significant increase in urine sugar, urine volume, fasting blood glucose, total cholesterol, triglycerides and low density lipoprotein, and decrease in high density lipoprotein were observed in the rats; however, these parameters were ameliorated in diabetic rats fed with diet supplemented withmango peel at 5% and 10% levels in basal diet. Treatment of diabetic rats with MPP increased antioxidant enzyme activities and decreased lipid peroxidation in plasma, kidney and liver compared to untreated diabetic rats. Glomerular filtration rate and microalbuminuria levels were ameliorated inMPP treated diabetic group. CONCLUSIONS: Mango peel, a by-product, can be used as an ingredient in functional and therapeutic foods.